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When it comes to non-surgical facial rejuvenation, injectable fillers are among the most popular options. Two of the most effective collagen-stimulating fillers are Sculptra® and Radiesse®. While both treatments restore lost volume and smooth wrinkles, they work differently and provide unique benefits.
If you’re deciding between Sculptra vs Radiesse, here’s everything you need to know before your consultation.
What Is Sculptra?
Sculptra is an injectable filler made from poly-L-lactic acid (PLLA). Instead of providing instant volume, it gradually stimulates your body’s natural collagen production. Results appear over several weeks and can last up to two years or more.
Best for:
- Gradual, natural-looking results
- Restoring facial volume loss (cheeks, temples, jawline)
- Long-lasting collagen stimulation
What Is Radiesse?
Radiesse is an injectable filler made from calcium hydroxylapatite (CaHA) microspheres. It provides both immediate volume and long-term collagen stimulation. Results are visible right away, with improvements continuing as collagen develops. Radiesse typically lasts 12–18 months.
Best for:
- Immediate lift and volume
- Smoothing deeper folds and wrinkles (nasolabial folds, marionette lines)
- Hand rejuvenation
Sculptra vs Radiesse: Key Differences
| Feature | Sculptra | Radiesse |
|---|---|---|
| Main Ingredient | Poly-L-lactic acid (PLLA) | Calcium hydroxylapatite (CaHA) |
| How It Works | Stimulates collagen gradually | Provides instant volume + collagen |
| Results Timeline | Gradual (weeks to months) | Immediate + progressive |
| Longevity | Up to 2+ years | 12–18 months |
| Best For | Volume restoration, subtle results | Deep wrinkles, folds, hand volume |
Which Injectable Is Right for You?
- Choose Sculptra if you want long-lasting, natural results that develop gradually.
- Choose Radiesse if you want instant volume and lift, especially for deeper wrinkles.
The best choice depends on your goals, treatment area, and personal preference—your injector will help customize the right plan.
Final Thoughts
Both Sculptra and Radiesse are powerful collagen-stimulating fillers that deliver natural, youthful results without surgery. The main difference lies in how quickly results appear and how long they last.